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Three types of learning and memory tests (Morris water maze, active and passive avoid- ance) were periormed in rats following intracerebroventricular infusion of ethylcholine aziridium (AF64A). In Morris water maze, AF64A-treated rats showed the delayed latencies to find the platform from 6th day after the inclusion. In pretrained rats, AF74A caused the significant delayed in latency at 7th day, but not 8th day. In the active avoidance for the pretrained rats, the escape latency was signifiantly delayed in AF64h-treatment. The percentages of avoidance in AF64A-treated rats were less increased than those in the control. Especial1y, the percentage of no response in the AF74A-treated rats was markedly increased in the first hah trials. In the passive avoidance, AF74A-treated rats shortened the latency 1.5h after the electronic shoct, but lot 24h. AF64A also caused the pretrained rats to shorten the latency 7th day after the infusion, but lot 8th day. These resulte indicate that AF64A might impair the learning and memory. However these results indicate that the disturbed memory by AF74A might rapidly recover aitei the first retrain. Furthermore, these results suggest that AF64A may be a useful agent for the animal model of learning for spatial cognition.
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